Atta-ur-Rahman School of Applied Biosciences
Researches AntiBacter Research Group

AntiBacter Research Group

AntiBacter Research Group
Group Lead : Dr Fazal Adnan

Lab Members

PhD Scholars 

Amna Jalil, Sidra Hafeez, Hira Niaz, Gul Naz, Hira Ikram

MS Scholars

Rabia Arjamand, Muhammad Khan, Hiba Shafique, Misbah

Research Associates:

Quratulain Farooq, Misha Zaib

Research Focus

1.Investing the antibiotic resisatance and zoonotic potential of avian and bovine pathogenic E. coli

2.Phage therapy; molecular characterization of bacteriophages to use them against bacteria

3.CRISRP-CAS mediated genome excision to target virulence/antibiotic resistance genes

4.Silencing of the bacterial toxins/virulent genes of E. coli via synthetic sRNA

For further details of the project please visit zoonotica.pk

Current Projects

International

  • Investigation of the antibiotic resistance and zoonotic potential of Avian Pathogenetic E. coli(APEC) and Mammary Pathogenic E. coli(MPEC) from poultry and bovine sources (Helmholtz, Germany PKR 5.5 Million)
  • Phage cocktail as therapeutic approach to combat colibacillosis in poultry (ZHAW LeadingHouse PKR 11.5 M)
  • GenomeTackr: Establishing the E. coli Reference database (FAO-FDA, USA PKR 14.5 Million)

National

  • CRISPR-CAS3 mediated whole genome excision of the Avian Pathogenic E. coli(APEC); a novel  strategy to combat colibacillosis in poultry birds”. (HEC- NRPU, Pakistan. 3.1 million PKR) Project competed in 2022
  • Silencing of the antibiotic resistancemecAgene via synthetic non-coding RNAs in the Staphylococcus    aureus”. (SRGP- HEC, Pakistan, PKR 0.5 M, Project completed in 2018).

Selected Publications

  • Jalil A, Masood S, Ain Q, Andleeb S, Dudley EG, Adnan F*. (Jun. 2023) High resistance of fluoroquinolone and macrolide reported in the Avian Pathogenic E. coli (APEC) isolates from the humid subtropical regions of Pakistan. J Glob Antimicrob Resist. 8:S2213-7165(23)00012-7. https://doi.org/10.1016/j.jgar.2023.01.009 . (IF 4.03)
  • Jalil, A.; Gul, S.; Bhatti, Adnan, Fazal*. (Dec. 2022) High Occurrence of Multidrug-Resistant E. coli Strains in Bovine Fecal Samples from Healthy Cows Serves as Rich Reservoir for AMR Transmission. Antibiotics 2023, doi.org/10.3390/antibiotics12010037 (IF 5.2)
  • lias Eger, Michael Schwabe, Lukas Schulig, Fazal Adnan, Katharina Schaufler (July 2022) Extensively drug-resistant Klebsiella pneumoniae counteracts fitness and virulence costs that accompanied ceftazidime-avibactam resistance acquisition, Microbiol Spectr. 2022 Jun 29;10(3):e0014822. doi: 10.1128/spectrum.00148-22. Epub 2022 Apr 18. PMID: 35435751; PMCID: PMC9241641. (IF 9.05)