Summary
Enviro Research Group Our laboratory focuses on research at the intersection of virology, proteomics, and translational medicine. We investigate the cellular defense mechanisms activated against viral infections, as well as the sophisticated strategies employed by viruses to manipulate, inhibit, and hijack host cellular pathways. In parallel, our research is dedicated to the development of next-generation cancer therapies based on nanoparticle-mediated drug delivery systems and virotherapy. We seek to enhance the precision, efficacy, and safety of cancer treatment by integrating targeted nanotechnology with virus-based therapeutic strategies. A central objective of our work is the design of innovative delivery platforms that improve selective targeting of tumor cells, maximize therapeutic response, reduce systemic toxicity, and ultimately improve patient outcomes. Our research employs a highly multidisciplinary approach, combining molecular virology, proteomics, cell culture, advanced microscopy, nanotechnology, and bioinformatics. By integrating experimental and computational methodologies, we aim to translate fundamental biological discoveries into clinically relevant therapeutic applications.Invitor to invivo studies along with all ADME profiling of any drug pharmokokinetics • Dynamic regulation of host–virus protein–protein and protein–nucleic acid interactions throughout the course of infection. • Molecular mechanisms underlying the sensing of pathogenic DNA within the nuclei of infected cells. • Initiation, coordination, and propagation of intrinsic and innate immune responses following infection with nuclear-replicating enteroviruses. • Therapeutic roles and clinical potential of PVSRIPO in the treatment of solid tumors, including prostate cancer. • Identification and characterization of host–pathogen signaling proteins within the tumor microenvironment, including mapping molecular interactions, determining interaction specificity, defining distinct protein complexes, and assessing the relative stability and dynamics of these interactions.
Academic Background
PhD
(Environmental Virology) University of the Punjab
August 23, 2016 - August 24, 2016
Honours and Awards
Research Grant
0.5 Million HEC Grant awarded Tile Molecular identification and characterization of Poliovirus from water bodies of Pakistan.
December 10, 2010
Bes Teacher Award
Best Teacher award (ASAB) the year 2018-19
December 24, 2019
Publications
Dose-Dependent Toxicological Effects of Polyvinyl Chloride and Polystyrene Microplastics on Wistar Albino Rats
February 07, 2026
Journal of Applied Toxicology - Pages 16
Surface functionalized hyaluronic acid coated chitosan nanoparticles for enhanced chloroquine delivery in triple-negative breast cancer
January 01, 2026
Journal of Drug Delivery Science and Technology - Volume 115, Part 1, Article Number 107654
Co-delivery of oncolytic virus and chemotherapeutic modality: Vincristine against prostate cancer treatment: A potent viro-chemotherapeutic approach
July 08, 2024
Journal of Medical Virology - Volume:96, Issue: 7, Article Number: e29748
Enhancing therapeutic efficacy: sustained delivery of 5-fluorouracil (5-FU) via thiolated chitosan nanoparticles targeting CD44 in triple-negative breast cancer
May 19, 2024
Scientific Reports - Volume:14, Issue:1, Article number: 11431
Development and characterization of SA/PEG hydrogel membranes with Ag/ZnO nanoparticles for enhanced wound dressing
April 15, 2024
Materials Chemistry and Physics - Volume 317, Article Number 129170
Aging and Synovial Joint Function: Changes in Structure and Implications for Mobility
March 27, 2024
Book on Advancements in Synovial Joint Science - Structure, Function, and Beyond - Chapter 2, Pages 1-16
A novel approach to insulin delivery via oral route: Milk fat globule membrane derived liposomes as a delivery vehicle
March 01, 2024
Saudi Journal of Biological Sciences - Volume 31, Issue 3, Article Number 103945
A multifunctional vanillin-infused chitosan-PVA hydrogel reinforced by nanocellulose and CuO-Ag nanoparticles as antibacterial wound dressing
February 01, 2024
International Journal of Biological Macromolecules - Volume:258, Article Number: 128831
In silico ADMET profling of Docetaxel and development of camel milk derived liposomes nanocarriers for sustained release of Docetaxel in triple negative breast cancer
January 09, 2024
Scientific Report - Volume 14, Article Number: 912
Antioxidant Activity of Carica papaya & Persea americana Fruits against Cadmium Induced Neurotoxicity, Nephrotoxicity, and Hepatotoxicity in Rats with a Computational Approach
January 01, 2024
Journal of Trace Elements in Medicine and Biology - Volume 81, Article Number 127324
Hepatitis E Virus: Epidemiology, Clinical Aspects, and Its Significance as a Major Pregnancy Risk
September 15, 2023
Livers - Volume:3, Issue:3, Page:507-528
Green synthesis of oncolytic Newcastle disease virus-loaded thiolated chitosan nanoformulation for CD44 targeted delivery and sustained release of virus in cervical cancer xenografts
August 12, 2023
Cancer Nanotechnology - Volume 14, Issue 1, Article Number 71
Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation
June 20, 2023
Cancer Nanotechnology - Volume 14, Issue 1, Article Number 65
CD44 targeted delivery of oncolytic Newcastle disease virus encapsulated in thiolated chitosan for sustained release in cervical cancer: a targeted immunotherapy approach
May 22, 2023
Frontiers in Immunology - Volume 14, Article Number 1175535
Recent Developments in Mpox Prevention and Treatment Options
February 21, 2023
Vaccines - Volume 11, Issue 3, Article Number 500
Respiratory Syncytial Virus Infection: Treatments and Clinical Management
February 20, 2023
Vaccines - Volume 11, Issue 2, Article Number 491
Green synthesis of hyaluronic acid coated, thiolated chitosan nanoparticles for CD44 targeted delivery and sustained release of Cisplatin in cervical carcinoma
January 12, 2023
Frontiers in Pharmacology - Volume 13, Article Number 1073004
Formulation for the Targeted Delivery of a Vaccine Strain of Oncolytic Measles Virus (OMV) in Hyaluronic Acid Coated Thiolated Chitosan as a Green Nanoformulation for the Treatment of Prostate Cancer: A Viro-Immunotherapeutic Approach
January 09, 2023
International Journal of Nanomedicine - Volume 18, Pages 185-205
miRNAs in Regulation of Tumor Microenvironment, Chemotherapy Resistance, Immunotherapy Modulation and miRNA Therapeutics in Cancer
November 01, 2022
International Journal of Molecular Sciences - Volume: 23, Issue: 22, Article Number: 13822
Review Article: Immune Landscape and Immunotherapy Options in Cervical Carcinoma
September 14, 2022
Cancers - Volume 14, Issue 18, Article Number 4458
Formulation of surface-functionalized hyaluronic acid-coated thiolated chitosan nano-formulation for the delivery of vincristine in prostate cancer: A multifunctional targeted drug delivery approach
August 01, 2022
Journal of Drug Delivery Science and Technology - Volume 74, Article Number 103545
Prevalence and assessment of associated risk factors of hepatitis B and C infections in low-socioeconomic communities
May 01, 2022
Future Virology - Volume 17, Issue 5, Pages 291-303
Targeting Acyl Homoserine Lactones (AHLs) by the quorum quenching bacterial strains to control biofilm formation in Pseudomonas aeruginosa
March 01, 2022
Saudi Journal of Biological Sciences - Volume 29, Issue 3, Pages 1673-1682
Serendipity for the intervention of COVID-19 and prostatic adenocarcinoma (PaC)
March 01, 2022
Prostate Cancer and Prostatic Diseases - Volume:25, Issue:1, Page:123-125
Advanced therapeutic options for treatment of metastatic castration resistant prostatic adenocarcinoma (mCRPC)
November 10, 2021
Frontiers in Pharmacology - journal
Hepatitis E virus genotyping in Pakistan: a regional study to explore the implications for pregnant females
September 02, 2021
Future Virology - Volume 16(9), Pages 611-617
6-deoxy-aminocellulose derivatives embedded soft gelatin methacryloyl (GelMA) hydrogels for improved wound healing applications: In vitro and in vivo studies
August 31, 2021
International Journal of Biological Macromolecules - Volume 185, Pages 419-433
TRAP transporter TakP; A key player in the resistance against selenite-induced oxidative stress in Rhodobacter sphaeroides
August 08, 2021
Microbiological Research - Volume 252, Article Number 126828
Fabrication and characterization of carbon-based nanocomposite membranes for packaging application
June 02, 2021
Polymer Bulletin - Pages 1-22
Potential approaches to combat COVID-19: a mini-review
December 01, 2020
Molecular Biology Reports - Volume 47, Pages 9939–9949
Association of hepatitis E seropositivity and altered progesterone levels in pregnant women of low socioeconomic status from capital region of Pakistan
December 01, 2020
Journal of the Pakistan Medical Association - Volume 70, Issue 12, Pages 2119-2123
Improving functional properties of PVA/starch-based films as active and intelligent food packaging by incorporating propolis and anthocyanin
November 18, 2020
Polymers & Polymer Composites - Pages 1-13
Pomegranate peel extract protects against carbon tetrachloride-induced nephrotoxicity in mice through increasing antioxidants status
September 01, 2020
Biomedical Reports - Volume 13(3), Article Number 13
Synthesis and Characterization of PVA/Starch Hydrogel Membranes Incorporating Essential Oils Aimed to be Used in Wound Dressing Applications
August 25, 2020
Journal of Polymers and the Environment - Pages 1-19
Anti-COVID-19 multi-epitope vaccine designs employing global viral genome sequences
August 01, 2020
PeerJ - Volume 8, Article Number e9541
In-Vitro and In-Vivo Study of Superabsorbent PVA/Starch/g-C3N4/Ag@TiO2 NPs Hydrogel Membranes for Wound Dressing
May 05, 2020
European Polymer Journal - Volume 130, Article Number 109650
PVA/starch/propolis/anthocyanins rosemary extract composite films as active and intelligent food packaging materials
February 01, 2020
Journal of Food Safety - Volume 40, Issue 1, Article Number e12725
Antibacterial activity of Mg1-xNixO(x¼0.5) nano-solid solution; experimental and computational approach
March 05, 2019
Journal of Molecular Structure - Volume: 1179 Pages: 347-353
Assessment of the risk for human health of Enterovirus and Hepatitis A virus in clinical and water sources from three metropolitan cities of Pakistan
December 20, 2018
Annals of Agricultural and Environmental Medicine - Volume 25, Issue 4, Pages 708-713
Preparation and Investigation of Ag Nanoparticles/TOPAS Nanocomposie Films for Packaging Applications
October 10, 2018
Current Nanoscience - Volume 14, Issue 6, Pages 538-544
Preparation and characterization of PVA/nanocellulose/Ag nanocomposite films for antimicrobial food packaging
March 15, 2018
Carbohydrate Polymer - Volume 184, Pages 453-464
Highly integrated nanocomposites of RGO/TiO2 nanotubes for enhanced removal of microbes from water
March 01, 2018
Environmental Technology - Volume 40, No. 19, Pages 2567–2576
Clinical and genetic studies in patients with Lafora disease from Pakistan
February 15, 2017
Journal of the Neurological Sciences - Volume: 373 Pages: 263-267 Published: FEB 15 2017
Development of Anti-bacterial PVA/Starch Based Hydrogel Membrane for Wound Dressing
January 31, 2017
Journal of Polymers and the Environment - Pages 1-9
Prevalence of rotavirus, adenovirus, hepatitis a virus and enterovirus in water samples collected from different region of Peshawar, Pakistan
December 01, 2016
Annals of Agricultural and Environmental Medicine - Volume 23, Issue 4, Pages 576-580
Protein Structure Modelling, Ligand Docking and Active Site Analysis of Mutated Poliovirus 2a Protease Gene Isolated From the Blood of Pakistani Polio Infected Patients
October 22, 2016
International Journal of Advances in Science Engineering and Technology - Vol-4, Iss-3, Spl. Issue-2
Frequency of hepatitis E and Hepatitis A virus in water sample collected from Faisalabad, Pakistan
December 10, 2015
Annals of Agricultural and Environmental Medicine - Volume 2, Issue 4, Pages 661-664
HCV, interferon therapy response, direct acting antiviral therapy revolution and Pakistan: future perspectives
November 25, 2015
Asian Pacific Journal of Cancer Prevention - Volume 16(13), Pages 5583-5584
Hepatitis C Virus Infection in Iran; Viral Spread Routes in General Population and Safety Measures
October 01, 2015
Hepatitis Monthly - Volume 15, Issue 10, Article Number:e17343
Berberine and neurodegeneration: A review of literature.
October 01, 2015
Pharmacological Reports - Volume 67, Issue 5, Pages, 970-979
Molecular confirmation of enterovirus from sewage and drinking water samples from three cities, Pakistan: a potential risk factor for public health
July 04, 2015
Southeast Asian Journal of Tropical Medicine and Public Health - Volume: 46, Issue:4, Pages 640-649
Structural modeling and analysis of dengue-mediated inhibition of interferon signaling pathway
April 28, 2015
Genetics and Molecular Research - Volume 14, Issue 2, Pages 4215-4237
Hospital Waste Management Awareness Attitude and Practices in Twin Cities of Pakistan
April 01, 2015
International Journal of Pharma and Bio Sciences - Volume 6(2), Pages 503-512
Epidemiological Characteristics of Poliomyelitis during the 21st century (2000-2013). International Journal of Public Health Science
September 01, 2014
International Journal of Public Health Science (IJPHS) - Volume 3, No.3, Pages 143~157
Comparison of HCV prevalence in Pakistan and Iran; An insight into future
January 12, 2014
Hepatitis Monthly - Volume 14, Issue 1, Article number e11466
Additional Glycosylation within a Specific Hypervariable Region of Subtype 3a of Hepatitis C Virus Protects Against Virus Neutralization
August 01, 2013
The Journal of Infectious Diseases - Volume 208, Issue 11, Pages 1888–1897
Mutations in the STAT1-interacting domain of the hepatitis C virus core protein modulate the response to antiviral therapy
August 01, 2013
Molecular Medicine Reports - Volume 8(2), Pages 487-92
Sequence and Structural Analysis of 3' Untranslated Region of Hepatitis C Virus, Genotype 3a, From Pakistani Isolates
May 09, 2013
Hepatitis Monthly - Volume: 13, Issue: 5, Article Number: UNSP e8390
Detection of Polio Virus in Municipal Water Bodies of Lahore, Pakistan
March 08, 2013
International Journal of Bioscience, Biochemistry and Bioinformatics - Volume 3 ,No. 2, Pages 157-160
Association of interleukin-10 polymorphism and malarial susceptibility in Pakistani population
June 03, 2012
Asian Biomedicine - Volume: 6, Issue: 3, Pages:337-342
Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice.
February 01, 2012
Nature Neuroscience - Volume 15, Issue 2, Pages 308-314
Association of IL-10 polymorphisms with hepatitis C infection susceptibility in Pakistani population
December 01, 2011
Journal of Infection in Developing Countries - Volume 5(6), Pages 473-479
Interleukin-10 gene promoter polymorphism as a potential host susceptibility factor in Pakistani patients with pulmonary tuberculosis.
October 26, 2011
Arican Journal of Biotechnology - Volume 10(66), Pages 14706-14710
Analysis of interleukin-10 gene polymorphisms and hepatitis C susceptibility in Pakistan
July 04, 2011
Journal of Infection in Developing Countries - Volume 5(6), Pages 473-479
Frequency of HEV contamination in sewerage waters in Pakistan
December 23, 2010
Journal of Infection in Developing Countries - Volume 4(12), Pages 842-845
PS3-53 Association of IL-10 polymorphisms with hepatitis C infection susceptibility in Pakistani population.
November 08, 2010
Cytokine - Volume 52(1-2), Page 92
Sequence comparison and phylogenetic analysis of core gene of hepatitis C virus from Pakistani population
July 19, 2010
African Journal of Biotechnology - Volume 9(29), Pages 4561-4567