Summary
Faculty, Healthcare Biotechnology; expertise in Molecular Virology and Immunology
Academic Background
PhD
(Molecular Virology) University of Veterinary & Animal Science
July 01, 2006 - February 17, 2011
Honours and Awards
PAMS-Young Scientist 2015
Pakistan Academy of Medical Sciences (PAMS) Young Scientist, Gold Medal, 2015
November 15, 2015
ASAB Best Innovator 2019
ASAB Best Innovator for the year 2019
September 25, 2020
ASAB Best Researcher 2017
ASAB Best researcher of the year 2017
November 20, 2017
Publications
In reply to the letter to the editor regarding “Bayesian evaluation of phage therapy efficacy against multidrug-resistant Acinetobacter Baumannii”
October 01, 2025
International Journal of Antimicrobial Agents - Volume:66, Issue: 4, Article Number:107555
Determine the frequency distribution of hepatocellular carcinoma (HCC) and evaluation of viral persistence in the development of HCC among Pakistani patients
September 01, 2025
Journal of the Pakistan Medical Association - Volume: 75, No. 09, Pages:1409-1416
Rhinoviruses Receptors and Their Interactions
September 01, 2025
Cell Signaling: Interplay, Mechanisms, and Therapeutic Implications - 1st Edition, Chapter 7, Pages: 07
Bayesian evaluation of phage therapy efficacy against multidrug-resistant Acinetobacter baumannii
August 01, 2025
International Journal of Antimicrobial Agents - Volume:66, Issue:2, Article Number 107508
The synergistic tapestry: unraveling the interplay of parvovirus B19 with other viruses
May 01, 2025
International Journal of Infectious Diseases - Volume:154, Article Number 107865
Prospects of Carica papaya in the treatment of human viral infections: A comprehensive and a systematic review
November 15, 2024
Heliyon - Volume:10, Issue:21, Article Numbe:e39635
Support Vector Machine Outperforms Other Machine Learning Models in Early Diagnosis of Dengue Using Routine Clinical Data
October 13, 2024
Advances in Virology - Volume 2024, Article ID 5588127, 9 pages
Chemical Profile, Antibacterial Activity and Antioxidant Activity of Bark Volatile Oil of Terminalia arjuna
October 01, 2024
Chemistry and Biodiversity - Volume: 21, Issue: 10, Article Number: e202400951
Enhancing CAR T cells function: role of immunomodulators in cancer immunotherapy
August 06, 2024
Clinical and Experimental Medicine - Volume 24, Article Number 180
Extracellular Vesicles Contribute to Viral-Induced Hepatocellular Carcinoma: Understanding Their Involvement in Viral Hepatitis and Their Potential as Biomarkers for Early Hepatocellular Carcinoma Detection
April 12, 2024
Viral Immunology - Vol: 37, No. 3, Pages:159-166 PubMed: 38588555
Machine Learning Based Diagnostic Paradigm in Viral and Non-Viral Hepatocellular Carcinoma
March 14, 2024
IEEE Access - Volume 12, Pages 37557-37571
The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis
February 14, 2024
Frontiers in Immunology - Volume 15, Article Number 1303115
Navigating the Brain: The Role of Exosomal Shuttles in Precision Therapeutics
January 18, 2024
Frontiers in Neurology - Volume 14, Article Number: 1324216, Pages: 17
Antioxidants and Calcium Modulators Preclude in Vitro Hepatitis B Virus–Induced Mitochondrial Damage
October 01, 2023
Turkish Journal of Gastroenterology - Volume 34, Issue 10, Pages 1052-1061
Interleukin-22 promotes the proliferation and migration of hepatocellular carcinoma cells via the phosphoinositide 3-kinase (PI3K/AKT) signaling pathway
July 01, 2023
Molecular Biology Reports - Volume 50, Issue 7, Pages 5957-5967
Pilot-scale production of highly durable bioactive and UV-protective cotton fabric by electroless deposition of copper oxide on cotton fabric
March 01, 2023
Cellulose - Volume:30, Issue:4, Page:2573-2595
Development of novel antiviral nanofnishes for bioactive textiles
September 15, 2022
Polymer Bulletin - Polymer Bulletin
P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis
May 20, 2022
PLoS ONE - Volume:17, Issue:5 May,
Emergence and Persistence of Resistance-Associated Substitutions in HCV GT3 Patients Failing Direct-Acting Antivirals
April 27, 2022
Frontiers in Pharmacology - Volume 13, Article Number 894460
Platelets’ RNA as biomarker trove for differentiation of early-stage hepatocellular carcinoma from underlying cirrhotic nodules
September 01, 2021
PLOS One - Volume 16(9), Article Number e0256739
The global emergence of Chikungunya infection: An integrated view
August 24, 2021
REVIEWS IN MEDICAL VIROLOGY - 2021;e2287. doi:10.1002/rmv.2287, 1-13
Direct‐acting antiviral agents in the treatment of chronic hepatitis C-Real‐life experience from clinical practices in Pakistan
December 01, 2020
Journal of Medical Virology - Volume 92, Issue 12, Pages 3475-3487
Comparative analysis of Bacterial Vaginosis microbiota among pregnant and non-pregnant females and isolation of phages against Enterococcus faecalis, Enterococcus faecium, and Shigella flexneri strains
December 01, 2020
Microbial Pathogenesis - Volume 149, Article Number 104588
Tumor educated platelets, a promising source for early detection of hepatocellular Carcinoma: liquid biopsy an alternative approach to tissue biopsy
November 01, 2020
Clinics and Research in Hepatology and Gastroenterology - Volume 44, Issue 6, Pages 836-844
Induction of Profibrotic Microenvironment via TLR4 MyD88-Dependent and -Independent Inflammatory Signaling in Chronic Hepatitis C Virus Infection
October 28, 2020
Viral Immunology - Volume 33 Issue 9, Pages 585-593
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
September 17, 2020
Frontiers in Immunology - Volume 11, Article Number 2148
Efficacy and Safety of Generic Sofosbuvir Plus Daclatasvir and Sofosbuvir/Velpatasvir in HCV Genotype 3-Infected Patients: Real-World Outcomes From Pakistan
September 02, 2020
Frontiers in Pharmacology - Volume 11, Article Number 550250
A comparative analysis of interferons and direct‐acting antivirals on the expression of genes involved in hepatitis C pathogenesis
July 24, 2020
Journal of Medical Virology - Pages 1-6
Mechanistic study of interaction between IL-22 and HCV core protein in the development of hepatocellular carcinoma among liver transplant recipients
May 01, 2020
Microbial Pathogenesis - Volume 142, Article Number 104071
CD81(+) Exosomes Play a Pivotal Role in the Establishment of Hepatitis C Persistent Infection and Contribute Toward the Progression of Hepatocellular Carcinoma
December 01, 2019
Viral Immunology - Vol. 32, No. 10, Pages 453-462
Role of purinergic receptors in hepatobiliary carcinoma in Pakistani population: an approach towards proinflammatory role of P2X4 and P2X7 receptors
September 01, 2019
Purinergic Signalling - Volume 15 Issue 3 Page: 367-374
Multifaceted role of cancer educated platelets in survival of cancer cells
May 01, 2019
THROMBOSIS RESEARCH - Volume 177 Pages 42-50
Pre-emptive dengue control strategy in Pakistan
April 01, 2019
Journal of Medical Virology - Volume 91, Issue 4, Pages 523-524
IL-22 in hepatocyte’s survival of Pakistani patients with end stage liver disease: an insight into IL 22 mediated hepato-regenerative pathway
February 01, 2019
Molecular Biology Reports - Volume 46, Issue 1, Pages 1127-1138
Bacterial vaginosis: An insight into the prevalence, alternative treatments regimen and it's associated resistance patterns
February 01, 2019
Microbial Pathogenesis - Volume: 127 Pages: 21-30
Purinoceptor expression in hepatocellular virus (HCV)-induced and non-HCV hepatocellular carcinoma: an insight into the proviral role of the P2X4 receptor
December 01, 2018
Molecular Biology Reports - Volume 45, Issue 6, Pages 2625-2630
Interleukin-6 Rescues Lymphocyte from Apoptosis and Exhaustion Induced by Chronic Hepatitis C Virus Infection
November 01, 2018
Viral immunology - Volume: 31 Issue: 9 Pages: 624-631
HCV non-structural NS4A protein of genotype 3a induces mitochondria mediated death by activating Bax and the caspase cascade
November 01, 2018
Microbial Pathogenesis - Volume: 124 Pages: 346-355
Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links
September 01, 2018
Hormones-International Journal of Endocrinology and Metabolism - Volume 17, Pages 299-313
Distribution of IL28B and IL10 polymorphisms as genetic predictors of treatment response in Pakistani HCV genotype 3 patients
April 01, 2018
Archives of Virology - NULL
Interleukin-6: A promising cytokine to support liver regeneration and adaptive immunity in liver pathologies
February 01, 2018
Cytokine and Growth Factor Reviews - Volume 39, Pages 36-45
Zika virus: what we need to know?
January 01, 2018
Journal of Basic Microbiology - NULL
Zika Virus: Immune Evasion Mechanisms, Currently Available Therapeutic Regimens, and Vaccines
December 01, 2017
Viral Immunology - NULL
In-Vitro Transcription analysis of NS5A from HCV-3a circulating in Pakistani patients with chronic hepatitis C and their differential response to antiviral therapy
October 02, 2017
Pakistan Journal of Medical Sciences - NULL
Hepatitis C virus induces oxidative stress and DNA damage by regulating DNAPKCs, ATM, ATR and PARP mediated signaling and guards cell from cancerous condition by upregulating RB, P53 and downregulating VEGF
August 28, 2017
Acta Virologica - Volume 61(3), Pages 316-323
Quantitative evaluation of insulin resistance markers in Pakistani patients suffering from HCV-associated type 2 diabetes mellitus
July 01, 2017
Acta Virologica - Volume: 61, Issue: 2, Pages: 197-203
PTEN: A potential prognostic marker in virus-induced hepatocellular carcinoma
June 16, 2017
Tumor Biology - Volume: 39, Issue: 6
Carcinoma-specific expression of P2Y(11) receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells
June 06, 2017
Oncotarget - Volume: 8, Issue: 23, Pages 37278-37290
Outbreak of chikungunya in Pakistan
March 01, 2017
The Lancet Infectious Diseases - Volume 17, No. 3, P258
Structural Evaluation of Purinergic Receptor (P2x4) Receptor Interaction With HCV Envelop Protein E1: A Potential Target For Drug
October 22, 2016
International Journal of Advances in Science, Engineering and Technology - Volume 4, Issue 3, Spl. Issue 2, Pages 58-62
HIV-1 and hijacking of the host immune system: the current scenario
October 01, 2016
APMIS - Volume 124, Issue 10, Pages 817-831
Molecular epidemiology and clinical features of Hepatitis C Virus (HCV) in epidemic areas of Interior Sindh, Pakistan
September 01, 2016
Pakistan Journal of Medical Sciences - Volume 32(5), Pages 1279-1282
Ionotropic Purinergic Receptors P2X4 and P2X7: Proviral or Antiviral? An Insight into P2X Receptor Signaling and Hepatitis C Virus Infection
September 01, 2016
Viral immunology - Vol.29(7), Pages 401-408
IL-22: a promising candidate to inhibit viral-induced liver disease progression and hepatocellular carcinoma
January 01, 2016
Tumour Biology - Volume 37(1), Pages 105-114
Hepatitis B virus therapy: What's the future holding for us?
November 28, 2015
World Journal of Gastroenterology - Volume 21, Issue 44, Pages 12558-12575
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis
November 21, 2015
World Journal of Gastroenterology - Volume 21, Issue 43, Pages 12361-12369
NS3-4A and NS4A proteins of hepatitis C virus regulate the apoptotic proteins expression in Huh-7 cells
November 14, 2015
International Journal of Biosciences - Volume 7, No. 5, Pages 9-15
Interleukin- 28B: a prognostic marker in interferon based therapy of chronic HCV patients of the Pakistan with variable treatment response
September 01, 2015
APMIS - Volume 123(9), Pages 765-771
Molecular characterization and fluorescence analysis of HCV non-structural proteins NS3, NS3-4A and NS4A of genotype 3a
August 31, 2015
Acta Virologica - Volume 59, No.3, Pages 284-294
Role of Interferon Gamma and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 1 Single Nucleotide Polymorphism in Natural Clearance and Treatment Response of HCV Infection
May 01, 2015
Viral Immunology - Volume 28, Number 4, Pages 222-228
Genetic variant of IL28B rs12979860, as predictive marker of interferon-based therapy in Pakistani population
April 01, 2015
APMIS - Volume 123(4), Pages 342-349
Contemplating the Importance of Toll-like Receptors I and II Regarding Human Viral Pathogenesis
January 01, 2015
Jundishapur Journal of Microbiology - Volume 8(1), Article Number e13348
Predictive potential of IL-18 -607 and osteopontin -442 polymorphism in interferon-based therapy of HCV infection in the Pakistani population
October 01, 2014
Viral Immunology - Volume 27, Issue 8, Pages 404-411
Hepatitis C virus infection in vitro triggers endoplasmic reticulum stress and downregulates insulin receptor substrates 1 and 2 through upregulation of cytokine signaling suppressor 3
September 03, 2014
Acta Virologica - Volume:58, Issue:3, Page:238-244
Current and future therapies for hepatitis C virus infection: From viral proteins to host targets
May 01, 2014
Archives of Virology - Volume 159, Issue 5, Pages 831-846
Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: A metabolic syndrome
May 01, 2014
Archives of Virology - Volume 159, Issue 5, Pages 1017-1025
Investigation of biomarkers in peripheral blood cells of Pakistani chronic HCV patients with genotype 3a: An assessment of HCV-induced pathogenesis
April 25, 2014
Future Virology - Volume 9, Issue 3, Pages 275-282
Correlation of OAS1 gene polymorphism at exon 7 splice accepter site with interferon-based therapy of HCV infection in Pakistan
April 01, 2014
Viral Immunology - Volume 27, Issue 3, Pages 105-111
Risk Factors Associated with Transmission of Hepatitis B and Hepatitis C Virus in Pakistan
January 01, 2014
Global Journal of Medical research: F Diseases - Volume 14, Issue 1, Pages 14-19
Transcript analysis of P2X receptors in pbmcs of chronic hcv patients: An insight into antiviral treatment response and hcv-induced pathogenesis
October 11, 2013
Viral Immunology - Volume 26, Issue 5, Pages 343-350
Role of viral and host factors in interferon based therapy of hepatitis C virus infection
October 01, 2013
Virology Journal - Volume 10, Article Number 299
Development of murine models to study Hepatitis C virus induced liver pathogenesis
September 14, 2013
Indian Journal of Virology - Volume 24, Issue 2, Pages 151-156
Identification of novel silent HIV propagation routes in Pakistan
August 12, 2013
World Journal of Virology - Volume 2(3), Pages 136-138
NOX4 induces oxidative stress and apoptosis through upregulation of caspases 3 and 9 and downregulation of TIGAR in HCV-infected Huh-7 cells
July 01, 2013
Future Virology - Volume 8, Issue 7, Pages 707-716
Phylogenetic analysis of torque teno virus genome from Pakistani isolate and incidence of co-infection among HBV/HCV infected patients
December 01, 2012
Virology Journal - Volume 9, Article Number 320
Poor oral health and coronary artery disease: A case-control study
November 01, 2012
Journal of Periodontology - Volume 83, Issue 11, Pages 1382-1387
Interaction of Hepatitis C virus proteins with pattern recognition receptors
June 22, 2012
Virology Journal - Volume 9, Article Number 126
An overview: In vitro models of HCV replication in different cell cultures
January 01, 2012
Infection, Genetics and Evolution - Volume 12, Issue 1, Pages 13-20
Hepatitis C Virus Infection: Molecular Pathways to Insulin resistance
October 18, 2011
Virology Journal - Volume 8, Article Number 474
Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a
September 08, 2011
Virology Journal - Volume 8, Article Number 431
Evaluation of three different hepatitis c virus typing methods for detection of mixed-genotype infections
June 01, 2011
Journal of Digestive Diseases - Volume 12, Issue 3, Pages 199-203
The changing epidemiology pattern and frequency distribution of hepatitis C virus in Pakistan
July 01, 2010
Infection, Genetics and Evolution - Volume 10, Issue 5, Pages 595-600
Hepatitis B virus YMDD-motif mutations with emergence of lamivudine-resistant mutants: a threat to recovery.
June 20, 2010
Gastroenterology and Hepatology from bed to bench - Volume 3(3), Pages 108-114
Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience
October 28, 2009
World Journal of Gastroenterology - Volume 15, Issue 40, Pages 5080-5085
Comparative efficacy of doxycycline and flumequine against experimentally induced colibacillosis in broiler chicks
August 30, 2009
Journal of Veterinary Medicine and Animal Health - Volume 1(2), Pages 017-022
Hepatitis C virus infection: A review of the current and future aspects and concerns in Pakistan
August 30, 2009
Journal of General and Molecular Virology - Volume 1(2), Pages 012-018, Article Number 3762AD010912
Nucleotide identity and variability among different Pakistani hepatitis C virus isolates
August 24, 2009
Virology Journal - Volume 6, Article Number 130
IGF-1 and G-CSF complement each other in BMSC migration towards infarcted myocardium in a novel in vitro model
June 01, 2009
Cell Biology International - Volume 33, Issue 6, Pages 650-657
Conferences
Disrupting HBV Persistence: Genetic Engineering Approach to Break the Oncogenic HBx Gene
May 05, 2025 - May 08, 2025
Saleha Resham, Haiqa Khan, Fazal Adnan, Sobia Manzoor,
International Conference on Material Sciences at SCME NUST
Tenured Associate Professor
ASAB
September 21, 2011 - February 25, 2022