Atta-ur-Rahman School of Applied Biosciences
Faculty Peter John

Peter John

Professor
Summary

Dr. John is Tenured Professor at Atta-Ur-Rahman School of Applied Biosciences (ASAB), NUST. Dr John has made an excellent progress in research, teaching & administration.

Academic Background
PhD (Molecular Biology/Biochemistry) Quaid-i-Azam University April 01, 2004 - February 07, 2008
Honours and Awards
Publications
Integrated Network Pharmacology and Molecular Modeling Approach for Potential PTGS2 Inhibitors against Rheumatoid Arthritis June 25, 2026 Current Pharmaceutical Design - Accepted
Clinical correlation of serum zinc and chromium levels in type 2 diabetes mellitus patients with complications in Pakistan: A Retrospective Study June 25, 2026 PeerJ - Accepted
Decoding pathogenic MMP9 variants in rheumatoid arthritis using computational and molecular dynamics approaches September 30, 2025 Scientific Reports - Volume:15, Issue:1, Article Number: 33743
Evaluation of Wheat Landrace Germplasm for Agronomic Disease Susceptibility and Quality Traits Using Kompetitive Allele-Specific PCR (KASP) Markers June 30, 2025 Anadolu Journal of Agricultural Sciences - Volume 40, No. 2, Pages 221-238
Networking Salt Inducible Kinase 1 Regulatory Perturbations on Type 2 Diabetes- Breast Cancer Co-Morbidity Associated Molecular Bridge January 22, 2025 The Euro Biotech Journal - Volume:9, Issue:1, Page:90-106
Phytochemical, Cytoprotective Profiling, and Anti-Inflammatory Potential of Colchicum luteum in Rheumatoid Arthritis: An Experimental and Simulation Study November 24, 2024 Nutrients - Volume 16(23), Article Number 4020
Evaluation of Inhibitory mechanism of Pennisetum glaucum (Pearl Millet) Bioactive Compounds for Rheumatoid Arthritis: An In Vitro and Computational Approach November 21, 2024 Frontiers in Pharmacology - Volume 15, Article Number 1488790
Study of Therapeutic Potential of Dodonaea viscosa against Rheumatoid Arthritis in Collagen Induced Arthritic Mouse Model October 17, 2024 The Euro Biotech Journal - Volume:8, Issue:4, Pages 230-242
Computational Insights into the Inhibitory Mechanism of Type 2 Diabetes Mellitus by Bioactive Components of Oryza sativa L. indica (Black rice) September 23, 2024 Frontiers in Pharmacology - Volume 15
Network medicine based approach for identifying the type 2 diabetes, osteoarthritis and triple negative breast cancer interactome: Finding the hub of hub genes August 22, 2024 Heliyon - Volume 10, Issue 17, Article Number e36650
Biocompatible gelatin-coated ferrite nanoparticles: A magnetic approach to advanced drug delivery June 01, 2024 Saudi Pharmaceutical Journal - Volume 32, Issue 6, Article Number:102066
Association analysis of Vascular Endothelial Growth Factor-A (VEGF-A) polymorphism in rheumatoid arthritis using computational approaches December 01, 2023 Scientific Reports - Volume 13, Issue 1, Article Number 21957
Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis September 20, 2023 Arthritis Research and Therapy - Volume 25, Issue 1, Article Number 176
Molecular Link between Glo-1 Expression and Markers of Hyperglycemia and Oxidative Stress in Vascular Complications of Type 2 Diabetes Mellitus August 23, 2023 Antioxidants - Volume 12(9), Article Number 1663
Integrated bioinformatics analyses identifying potential biomarkers for type 2 diabetes mellitus and breast cancer: In SIK1-ness and health August 09, 2023 PLOS ONE - Volume 18, Issue 8, Article Number e0289839
Molecular dynamics simulations and bioinformatics’ analysis of deleterious missense single nucleotide polymorphisms in Glyoxalase-1 gene February 22, 2023 Journal of Biomolecular Structure and Dynamics - Pages 1-11
Computational analysis to investigate the anti-rheumatic potential of plant-based small molecule inhibitor targeting tumor necrosis factor α February 07, 2023 Frontiers in Pharmacology - Volume 14, Article Number 1127201
Regenerable sensor based on tris(4,7′-diphenyl-1,10-phenanthroline)ruthenium (II) for anodic and cathodic electrochemiluminescence applications February 01, 2023 Bioelectrochemistry - Volume 149, Article Number 108313
Association of Fc Gamma Receptor 3B Gene Copy Number Variation with Rheumatoid Arthritis Susceptibility November 29, 2022 Genes - Volume 13, Issue 12, Article Number 2238
Thymus serpyllum Exhibits Anti-Diabetic Potential in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice: A Combined Biochemical and In Vivo Study August 29, 2022 Nutrients - Volume 14, Issue 17, Article Number 3561
Challenges and opportunities in healthcare biotechnology August 19, 2022 Book on Biotechnology in Healthcare: Applications and Initiatives - Chapter 18, Pages 321-342
Evaluation of Antidiabetic Activity of Biogenic Silver Nanoparticles Using Thymus serpyllum on Streptozotocin-Induced Diabetic BALB/c Mice August 01, 2022 Polymers - Volume 14, Issue 15, Article Number 3138
Docking and Molecular Dynamics Study to Identify Novel Phytobiologics from Dracaena trifasciata against Metabolic Reprogramming in Rheumatoid Arthritis July 29, 2022 Life - Volume 12, Issue 8, Article Number 1148
LC-MS/MS-Based Serum Protein Profiling for Identification of Candidate Biomarkers in Pakistani Rheumatoid Arthritis Patients March 21, 2022 Life - Volume 12, Issue 3, Article Number 464
Biogenic Selenium Nanoparticles: Potential Solution to Oxidative Stress Mediated Inflammation in Rheumatoid Arthritis and Associated Complications August 05, 2021 Nanomaterials - Volume 11, Article Number 2005
The prognostic outcome of ‘type 2 diabetes mellitus and breast cancer’ association pivots on hypoxia-hyperglycemia axis July 05, 2021 Cancer Cell International - Volume 21, Article Number: 351
In silico analysis of non-synonymous missense SNPs (nsSNPs) in CPE, GNAS genes and experimental validation in type II diabetes mellitus through Next Generation Sequencing July 01, 2021 Genomics - Volume 113, Issue 4, Pages 2426-2440
Emerging role of selenium in treatment of rheumatoid arthritis: An insight on its antioxidant properties July 01, 2021 Journal of Trace Elements in Medicine and Biology - Volume 66, Article Number 126737
Assessment of genetic risk of type 2 diabetes among Pakistanis based on GWAS-implicated loci May 30, 2021 Gene - Volume 783, Article Number 145563
Regulatory MicroRNAs in T2DM and Breast Cancer May 08, 2021 Processes - Volume 9(5), Article Number 819
Molecular docking and pharmacophore models to probe binding hypothesis of inhibitors of hypoxia inducible factor-1 April 24, 2021 Journal of Biomolecular Structure and Dynamics - Pages 1-12
Structural and functional annotation of PR/SET Domain (PRDM) protein family: In-silico study elaborating role of PRDM12 mutation in congenital insensitivity to pain December 01, 2020 Computational Biology and Chemistry - Volume 89, Article Number 107382
Association of VPREB1 Gene Copy Number Variation and Rheumatoid Arthritis Susceptibility October 08, 2020 Disease Markers - Volume 2020, Article ID 7189626, 5 pages
A sequencing study of CTLA4in Pakistani rheumatoid arthritis cases September 18, 2020 PLoS ONE - Volume 15(9), Article Number e0239426
Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice May 15, 2020 International Journal of Nanomedicine - Volume 15, Pages 3497-3509
Pan-transcriptomics and its applications March 13, 2020 Book on Pan-genomics: Applications, Challenges, and Future Prospects - Chapter 18, Pages 343-356
Tomorou Attenuates Progression of Rheumatoid Arthritis through Alteration in ULK-1 Independent Autophagy Pathway in Collagen Induced Arthritis Mice Model November 07, 2019 Cell Death Discovery - Volume 5, Article Number: 142, Pages 1-13
Therapeutic Potential Of Foeniculum vulgare Mill. Derived Selenium Nanoparticles In Arthritic Balb/c Mice October 31, 2019 International Journal of Nanomedicine - Volume 14, Pages 8561-8572
Nanomedicine: an emerging era of theranostics and therapeutics for rheumatoid arthritis October 01, 2019 Rheumatology - Volume 58, Issue 10, Pages 1715–1721
Exploration of shared genetic susceptibility loci between type 1 diabetes and rheumatoid arthritis in the Pakistani population August 27, 2019 BMC Research note - Volume 12, Article Number: 544
Single-Cell Omics in Autoimmune Disorders August 16, 2019 Single-Cell Omics - Chapter 9, Volume 2 (Application in Biomedicine and Agriculture) 2019, Pages 165-174
Single-Cell Omics in Metabolic Disorders August 10, 2019 Single-Cell Omics - Volume 2: Advances in Applications, Pages 153-164
Comprehensive Computational Analysis of Protein Phenotype Changes Due to Plausible Deleterious Variants of Human SPTLC1 Gene May 13, 2019 International Journal of Molecular and Cellular Medicine - Volume 8, No 1
Vitamin D as a Principal Factor in Mediating Rheumatoid Arthritis-Derived Immune Response May 07, 2019 BioMed Research International - Article Number 3494937
Identification of recombinants carrying stripe rust resistance gene Yr57 and adult plant stem rust resistance gene Sr2 through marker‐assisted selection April 01, 2019 Plant Breeding - Volume 138, Issue 2, Pages 148-153
Lack of association of –863C/A (rs1800630) polymorphism of tumor necrosis factor-a gene with rheumatoid arthritis March 01, 2019 Archives of Medical Science - Volume: 15, Issue: 2, Pages 531-536
Co-expression of HIF-1α, MDR1 and LAPTM4B in peripheral blood of solid tumors February 07, 2019 PeerJ - Volume 7, Article Number e6309
Karnal Bunt Resistance in Synthetic Hexaploid/Bread Wheat Derivatives December 01, 2018 NUST Journal of Natural Sciences - Volume 4, Issue: 1, Pages .83-99
Ethical Issues in Genomics December 01, 2018 NUST Journal of Natural Sciences - Volume 4, Issue: 1, Pages 20-29
Interlace between Chromatin Structure, DNA Repair and Ubiquitination August 01, 2018 Ubiquitination Governing DNA Repair - Implications in Health and Disease - Chapter 7
Resistance potential of Pakistani wheat landraces (Triticum aestivum L.) against stripe rust (puccinia striformis) and karnal bunt (tilletia indica) August 01, 2018 Pakistan Journal of Botany - Volume 50(2), Pages 801-806
Epidemiological Investigation of Type 2 Diabetes and Alzheimer's Disease in a Pakistani Population August 01, 2018 International Journal of Environmental Research and Public Health - Volume: 15 Issue: 8 Article Number: 1582
T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis April 01, 2018 Cytokine - Volume 104, Pages 130-135
Therapeutic Potential of Selenium Nanoparticles February 23, 2018 Journal of Nanomedicine and Nanotechnology - Volume 9, Issue 1, 1000487, online published on 21 Feb 2018
Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice February 01, 2018 Inflammopharmacology - Volume 26(1), Pages 157-170
Identification and in silico analysis of functional SNPs of human TAGAP protein: A comprehensive study January 12, 2018 PLoS ONE - Volume: 13, Issue: 1, Article Number: e0188143
Case-control study of vitamin D receptor gene polymorphism in Pakistani rheumatoid arthritis patients December 01, 2017 Revista Brasileira de Reumatologia (English Edition) - Volume 57, Issue 6, Pages 633-636
Association of rs182429 variant in TAGAP with rheumatoid arthritis in Pakistani population December 01, 2017 Meta Gene - Volume 14, Pages 59-63
Reverse Engineering and Its Applications December 01, 2017 Omics Technologies and Bio-engineering : Towards Improving Quality of Life - Volume 1, Chapter 5, Pages 95-110
In-Silico characterization of SCN9A: A protein that mediates voltage-dependent sodium ion permeability of excitable membranes November 30, 2017 International Journal of Biosciences - Volume 11, No. 5, Pages 378-385
Progression pattern of rheumatoid arthritis: A study of 500 Pakistani patients July 01, 2017 Pakistan Journal of Pharmaceutical Sciences - Vol. 30, Issue 4, Pages 1219-1223
The Mantle of Advanced Glycation end Products in Micro-and Macrovascular Complications of Type 2 Diabetes Mellitus June 30, 2017 Current Research in Diabetes and Obesity Journal - Volume 2, Issue 5, Article Number 555596
Assessment of Pakistani and Iranian Bread Wheat Landraces using Multivariate Analysis for Grain Yield June 01, 2017 Pakistan Journal of Botany - Volume: 49 Issue: 6 Pages: 2451-2458
Mapping Autosomal Recessive Intellectual Disability: Combined Microarray and Exome Sequencing Identifies 26 Novel Candidate Genes in 192 Consanguineous Families April 01, 2017 Molecular Psychiatry - Vol. 23(4), Pages 973-984
Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia March 01, 2017 Clinical Genetics - Volume 91, Issue 3, Pages 494-498
A replication study of 49 Type 2 diabetes risk variants in a Punjabi Pakistani population August 01, 2016 Diabetic Medicine - Volume 33, Issue 8, Pages 1112-1117
Polymorphisms in DNA repair genes XRCC1 and OGG1 lead to the progression of rheumatoid arthritis in Pakistani patients July 01, 2016 Pakistan Journal of Pharmaceutical Sciences - Volume 29, No.4, Pages 1189-1195
Prevalence of type 2 diabetes-associated complications in Pakistan June 01, 2016 International Journal of Diabetes in Developing Countries - Volume 36, Issue 2, Pages 179-188
Homozygous mutations in NTRK1 gene underlie congenital insensitivity to pain with anhidrosis in Pakistani families June 01, 2016 Neurology Asia - Volume 21(2), Pages 129-136
The microRNA regulatory network: a far-reaching approach to the regulate the Wnt signaling pathway in number of diseases June 01, 2016 Journal of Receptors and Signal Transduction - Volume 36(3), Pages 310-318
Association of Non-Genetic Risk Factors with Coronary Artery Disease in Pakistani Population June 01, 2016 Annals of PIMS - Volume 12(2), Pages 98-102
Lack of tumor necrosis factor alpha gene polymorphism -857c/t (rs1799724) association in Pakistani rheumatoid arthritis patients April 28, 2016 International Journal of Rheumatic Diseases - 4 pages
Identification of a homozygous missense mutation in LRP2 and a hemizygous missense mutation in TSPYL2 in a family with mild intellectual disability April 01, 2016 Psychiatric Genetics - Volume 26(2), Pages 66-73
Electrochemiluminescence of Luminol-Tripropylamine System April 01, 2016 Electrochimica Acta - Volume 196, Pages 245-251
Rheumatoid arthritis: What have we learned about the causing factors? March 01, 2016 Pakistan Journal of Pharmaceutical Sciences - Volume 29, No.2, Pages 629-645
Chemiluminescence of creatinine/H2O2/Co(2+) and its application for selective creatinine detection January 15, 2016 Biosensors and Bioelectronics - Volume 75, Pages 347-351
Signating Pathways Involved in Rheumatoid Arthritis: Targets for New Therapeutic Interventions December 01, 2015 NUST Journal of Natural Sciences - Volume 3, No. 1, Pages 53-64
RANKL Signating Pathway: A potential Target for Antiresorptive Therapy in Rheumatoid Arthritis December 01, 2015 NUST Journal of Natural Sciences - Volume 3, No. 1, Pages 35-52
Pharmacogenomics of Type 2 Diabetes Mellitus: A Step Toward Personalized Medicine December 01, 2015 NUST Journal of Natural Sciences - Volume 3, No. 1, Pages 19-26
Data interpretation: deciphering the biological function of Type 2 diabetes associated risk loci August 01, 2015 Acta Diabetologica - Volume 52, Pages789-800
Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment June 01, 2015 Human Molecular Genetics - Volume 24(11), Pages 3172-3180
Feeding of organic plant extracts to animals during vivisection, extract dosage feeding formula (exdff): a novel technique June 01, 2015 Basic Research Journal of Agricultural Science and Review - Volume 4(6), Pages 172-175
Genetic link of type 1 diabetes susceptibility loci with rheumatoid arthritis in Pakistani patients June 01, 2015 Immunogenetics - Volume 67, Issue 5-6, Pages 277-282
Association of 32 type 1 diabetes risk loci in Pakistani patients April 01, 2015 Diabetes Research and Clinical Practice - Volume 108, Issue 1, Pages 137-142
Homozygosity mapping of autosomal recessive intellectual disability loci in 11 consanguineous Pakistani families February 01, 2015 Acta Neuropsychiatrica - Volume 27, Issue 1, Pages 38-47
Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder November 01, 2014 Human Genetics - Volume 133, Issue 11, Pages 1419-1429
Association of Pro12Ala (rs1801282) variant of PPAR gamma with Rheumatoid Arthritis in a Pakistan population May 01, 2014 Rheumatology International Clinical and Experimental Investigations - Volume 34, Issue 5, Pages 699-703
Anti-citrullinated protein antibodies: role in pathogenesis of RA and potential as a diagnostic tool July 01, 2013 Rheumatology International - Volume:33, Issue:7, Pages: 1669-1673
A Study of Interleukin-15 (IL 15) Gene Polymorphism in Pakistani Patients with Rheumatoid Arthritis (RA) June 04, 2013 International Journal of Genetics - Volume 05, Issue 02, Pages 139-141
Replication of European Rheumatoid Arthritis Loci in a Pakistani Population April 01, 2013 Journal of Rheumatology - Volume 40(4), Pages 401-407
MicroRNA-155 as a therapeutic target for inflammatory diseases March 01, 2013 Rheumatology International - Volume 33, Issue 3, Pages 557-560
Genetic Susceptibility to Type 2 Diabetes and Implications for Therapy January 01, 2013 Journal of Diabetes & Metabolism - Volume 4, Issue 3, Article No. 1000248, 2013
Conferences
Zingiber officinale Roscoe Attenuates Metabolic Dysregulation in Streptozotocin-Induced Type 2 Diabetic Mice: An Integrated Biochemical and In Vivo Analysis September 11, 2025 - September 13, 2025 Peter John, Attya Bhatti, European Biotechnology Congress 2025
Association of TCF7L2 Genetic Polymorphism with Type 2 Diabetes in Pakistani Patients February 17, 2023 - February 18, 2023 Prof Attya Bhatti, Prof Peter John, Hadiqa Mubashir, EUROASIA Congress on Scientific Researches and Recent Trends-X
Pro-Inflammatory, Anti-Oxidative, Therapeutic Potential of Moringa Oleifera in Rheumatoid Arthritis February 16, 2023 - February 17, 2023 Peter John, Attya Bhatti, Safa Bajwa, Euroasia International Congress on Scientific Research and Recent Trends-X
Data Integration for Big Data analytics to identify the gaps in Rheumatoid Arthritis Genomics in a Post-GWAS era April 28, 2022 - April 29, 2022 Prof. Dr Attya Bhatti, Sidrah Jahangir, Peter John, Muhammad Muaaz Aslam, 2022 2nd International Conference on Advance Computing and Innovative Technologies in Engineering, ICACITE 2022
Therapeutic Potential of Thymus serpyllum in Collagen Induced Arthritic Mice July 05, 2021 - July 06, 2021 Peter John, Arooma Janat, Attya Bhatti, 4th HEALTH SCIENCES AND INNOVATION CONGRESS